Acetic Acid → N-(2-hydroxyethyl)-N-methylmesitylenesulphonamide mesitylenesulphonate

反応式

[C:1]1([CH3:13])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[S:9](Cl)(=[O:11])=[O:10].[CH3:14][NH:15][CH2:16][CH2:17][OH:18].C(O)(=O)C>N1C=CC=CC=1>[C:1]1([CH3:13])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[S:9]([OH:18])(=[O:11])=[O:10].[OH:18][CH2:17][CH2:16][N:15]([CH3:14])[S:9]([C:2]1[C:3]([CH3:8])=[CH:4][C:5]([CH3:7])=[CH:6][C:1]=1[CH3:13])(=[O:11])=[O:10]

参加物

実験手順

66 g (0.3 mole) mesitylenesulphonyl chloride in 37.5 ml pyridine were added dropwise at -5° C. to 11.2 g (0.015 mole) 2-methylaminoethanol. The reaction mixture was kept in a cooler (4° C.) overnight and then poured on ice. 20 ml acetic acid were added and the product was washed with water, taken up in diethyl ether, washed with water and dried with Na2SO4. The solvent was removed in vacuum, giving 55.7 g pale yellow crystals of the title compound, m.p. 94° C.