Phenol → 4-(1,1-diphenylethyl)phenol

HRID 1856366ノート

反応式

HRID 1856366 の反応式
[C:1]1([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:15]1([OH:21])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.C(=O)([O-])O.[Na+]>>[C:1]1([C:7]([C:18]2[CH:19]=[CH:20][C:15]([OH:21])=[CH:16][CH:17]=2)([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 4

HCID 996PhenolHCID 6101p-Toluenesulfonic acid2 回HCID 107401,1-DiphenylethyleneHCID 516892Sodium Bicarbonate

生成物 1

HCID 2450614-(1,1-diphenylethyl)phenol

実験手順

1,1-Diphenylethylene and phenol in an excess amount were heated in an oil bath at 140° to 150° C. for 1 hour in the presence of p-toluenesulfonic acid. After being allowed to cool, p-toluenesulfonic acid was neutralized using sodium hydrogencarbonate and the excess phenol was then removed by steam distillation to obtain p-(1,1-diphenylethyl)phenol. The resulting phenol was then subjected to carboxylation by the Kolbe reaction according to the process described in Synthesis Example 1 to obtain Compound (4) which was then converted into the zinc salt by the same process as that described in Synthesis Example 2.

後処理

  1. temperatureto cool
  2. customthe excess phenol was then removed by steam distillation

出典と根拠

ORDレコード
ord-9a33e9db65c041ca84efa519609bf79b
出典データセット
uspto-grants-1980_08
特許番号
US04219219

反応ノート

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