HCID 131722148、化合物 → 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionic acid
反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([S:8]([CH2:11][C@H:12]([CH3:23])[C:13]([O:15]CC2C=CC=CC=2)=[O:14])(=[O:10])=[O:9])[CH2:4][CH2:3]1>CO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([S:8]([CH2:11][C@H:12]([CH3:23])[C:13]([OH:15])=[O:14])(=[O:10])=[O:9])[CH2:6][CH2:7]1参加物
4
実験手順
A 100 mL Fisher/Porter vessel was charged with benzyl 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionate in 15 mL MeOH with a catalytic amount of 10% Pd-C. Hydrogenation at 50 psi for 48 hours afforded, after filtration through Celite and concentration in vacuo to yield 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionic acid as a hygroscopic foam suitable for use without further purification.
後処理
- customHydrogenation at 50 psi for 48 hours afforded
- filtrationafter filtration
- concentrationthrough Celite and concentration in vacuo
出典と根拠
- ORDレコード
- ord-2bc00d4649e54810aab0e54ca47c6764
- 出典データセット
- uspto-grants-2000_11
- 特許番号
- US06143747
反応ノート
読み込み中…