HCID 18738447、化合物 → 3-((dimethylamino)sulfonyl]-2(R)-methylpropionic acid
反応式
[CH3:1][N:2]([CH3:19])[S:3]([CH2:6][C@H:7]([CH3:18])[C:8]([O:10]CC1C=CC=CC=1)=[O:9])(=[O:5])=[O:4]>C(O)(=O)C.[Pd]>[CH3:19][N:2]([CH3:1])[S:3]([CH2:6][C@H:7]([CH3:18])[C:8]([OH:10])=[O:9])(=[O:4])=[O:5]参加物
4
実験手順
A 100 mL Fisher/Porter vessel was charged with 1.4 g of benzyl 3-[(dimethylamino)sulfonyl]-2(R)-methylpropionate in 30 mL acetic acid with a catalytic amount of 10% Pd-C. The reaction was hydrogenated at 50 psi for 24 hours, filtered through Celite and concentrated in vacuo. The residue was azeotroped with toluene then concentrated in vacuo to afford 900 mg of 3-[(dimethylamino)sulfonyl]-2(R)-methylpropionic acid which was used without further purification.
後処理
- filtrationfiltered through Celite
- concentrationconcentrated in vacuo
- customThe residue was azeotroped with toluene
- concentrationthen concentrated in vacuo
出典と根拠
- ORDレコード
- ord-33d6e8107c6644c1b5a33ee8c2ea1431
- 出典データセット
- uspto-grants-2000_11
- 特許番号
- US06143747
反応ノート
読み込み中…