Sodium Azide → 6-(3-Azidopropoxy)carbostyril
反応式
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:16])[CH:10]=[CH:9]2.[N-:17]=[N+:18]=[N-:19].[Na+]>CN(C)C=O>[N:17]([CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:16])[CH:10]=[CH:9]2)=[N+:18]=[N-:19]参加物
4
反応条件
- 温度
- 80 °C
実験手順
A suspension of 6-(3-chloropropoxy)carbostyril (100 g) and sodium azide (33 g) in dimethylformamide is refluxed at 80° C. for 4 hours. After the mixture is allowed to cool, to the mixture is added ice-water, and the precipitated crystals are collected by filtration, washed with diethyl ether, and dried to give 6-(3-azidopropoxy)carbostyril (100 g) as a white powder.
後処理
- temperatureto cool, to the mixture
- filtrationthe precipitated crystals are collected by filtration
- washwashed with diethyl ether
- customdried
出典と根拠
- ORDレコード
- ord-2ca5e81abc2e4b138cef66f3ed51cc9c
- 出典データセット
- uspto-grants-2000_11
- 特許番号
- US06143763
反応ノート
読み込み中…