2-Methylterephthalic acid → N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-(4-methoxycarbonylphenyl)carboxamide

HRID 1857150

反応式

HRID 1857150 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1.C[C:24]1[CH:32]=[C:31]([C:33]([OH:35])=[O:34])[CH:30]=[CH:29][C:25]=1[C:26]([OH:28])=O.Cl.[CH2:37](N=C=NCCCN(C)C)C>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:17]=[CH:18][C:19]([NH:22][C:26]([C:25]2[CH:24]=[CH:32][C:31]([C:33]([O:35][CH3:37])=[O:34])=[CH:30][CH:29]=2)=[O:28])=[CH:20][CH:21]=1

参加物

5

反応物 3

HCID 2280862-Methylterephthalic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 115945434-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline

生成物 1

HCID 22132633N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-(4-methoxycarbonylphenyl)carboxamide収率 64%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (100 mg) and commercially available monomethylterephthalic acid (130 mg) were dissolved in N,N-dimethylformamide (4 ml), 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride (227 mg) was added, and the admixture was stirred at room temperature for 18 hours. The reaction mixture was then purified in the same manner as described in Example 51 to obtain 99 mg of the title compound (yield: 64%).

後処理

  1. customThe reaction mixture was then purified in the same manner

出典と根拠

ORDレコード
ord-0087767f0f144aa888556ad8510f7e9c
出典データセット
uspto-grants-2000_11
特許番号
US06143764

関連ノート

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