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2-Nitrophenol → N-(4-Butylphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}urea

HRID 1857166
ノート
印刷プレビュー

反応式

HRID 1857166 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N+]([O-])=O.[N+:25](C1C=CC=CC=1O)([O-])=O.[CH2:35]([C:39]1[CH:44]=[CH:43][C:42]([N:45]=[C:46]=[O:47])=[CH:41][CH:40]=1)[CH2:36][CH2:37][CH3:38]>C1(C)C=CC=CC=1>[CH2:35]([C:39]1[CH:44]=[CH:43][C:42]([NH:45][C:46]([NH:25][C:19]2[CH:20]=[CH:21][C:16]([O:15][C:6]3[C:5]4[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=4)[N:9]=[CH:8][CH:7]=3)=[CH:17][CH:18]=2)=[O:47])=[CH:41][CH:40]=1)[CH2:36][CH2:37][CH3:38]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 69472-NitrophenolHCID 27963134-Butylphenyl isocyanateHCID 221326976,7-Dimethoxy-4-(2-nitrophenoxy)quinoline

生成物 1

HCID 22132682N-(4-Butylphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}urea収率 50%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

6,7-Dimethoxy-4-(2-aminophenoxy)quinoline (56 mg), which was obtained, analogously to Example 49, by reducing 6,7-dimethoxy-4-(2-nitrophenoxy)quinoline obtained in the same manner as described in Example 48, except that 2-nitrophenol was used in place of 4-nitrophenol, was dissolved in toluene (3 ml) with heat, 4-n-butylphenyl isocyanate (0.2 ml) was added, and the admixture was refluxed with heat for 30 minutes. The resulting residue was purified by chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 45 mg of the title compound (yield: 50%).

後処理

  1. customobtained in the same manner
  2. temperaturewith heat
  3. temperaturethe admixture was refluxed
  4. temperaturewith heat for 30 minutes
  5. customThe resulting residue was purified by chromatography on silica gel eluting with chloroform/acetone (10/1)

出典と根拠

ORDレコード
ord-4d7ffb8cb31941cab6b331e987539a2e
出典データセット
uspto-grants-2000_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06143764

反応ノート

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