3-Hydroxybenzophenone → {3-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}phenylmethanone

反応式

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[OH:16][C:17]1[CH:18]=[C:19]([CH:28]=[CH:29][CH:30]=1)[C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:21]>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][CH:3]=[C:2]2[O:16][C:17]1[CH:18]=[C:19]([C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:21])[CH:28]=[CH:29][CH:30]=1

参加物

反応物 2

HCID 830503-Hydroxybenzophenone

HCID 4596104-Chloro-6,7-dimethoxyquinoline

生成物 1

HCID 53907205{3-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}phenylmethanone収率 65.3%

反応条件

温度: 170 °C

実験手順

A mixture of 4-chloro-6,7-dimethoxyquinoline (112 mg) and commercially available 3-hydroxybenzophenone (297 mg) was stirred at 170° C. for 10 minutes, the reaction mixture was then purified by thin layer chromatography on silica gel eluting with hexane/acetone (2/1) to obtain 126 mg of the title compound (yield: 65%).

後処理

customthe reaction mixture was then purified by thin layer chromatography on silica gel eluting with hexane/acetone (2/1)

出典と根拠

ORDレコード: ord-a2e9c24a256f4eb3a7ffd7bf2e26bd73
出典データセット: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06143764

反応ノート

読み込み中…