Acetic Acid → HCID 22125747、化合物

HRID 1858040ノート

反応式

HRID 1858040 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH2:17]1N2CN3CN(C2)CN1C3.Cl.[OH2:28].[C:29](O)(=[O:31])C>>[CH:17]([C:3]1[C:2]([OH:1])=[C:7]([O:8][CH3:9])[CH:6]=[C:5]([CH:29]=[O:31])[C:4]=1[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[O:28]

参加物

6

反応物 5

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 962WaterHCID 4101HexamethylenetetramineHCID 2693075-(3-Hydroxy-4-methoxyphenyl)pentanoic acid

生成物 1

HCID 22125747HCID 22125747、化合物

実験手順

5-(3-Hydroxy-4-methoxyphenyl)pentanoic acid (8 g) and hexamethylenetetramine (10 g) in acetic acid (150 ml) were heated under reflux over night. 70 ml 6 M Hydrochloric acid was added to the reaction mixture and it was refluxed for half an hour. The mixture was poured into water and extracted with dichloromethane. The organic phase was evaporated in vacuo and the residue triturated with diethyl ether. Yield 3.04 g.

後処理

  1. temperatureunder reflux over night
  2. temperaturewas refluxed for half an hour
  3. extractionextracted with dichloromethane
  4. customThe organic phase was evaporated in vacuo
  5. customthe residue triturated with diethyl ether

出典と根拠

ORDレコード
ord-f87af0678acd4e1ea86614ad9164451c
出典データセット
uspto-grants-2000_11
特許番号
US06150412

反応ノート

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