Trifluoroacetic acid → 1-[7-Chloro-2-oxo-4-(2-piperidin-2-yl-ethoxy)-3-thiophen-2-yl-1,2-dihydroquinolin-6-yl]-3-pyridin-4-yl-urea

HRID 1858169ノート

反応式

HRID 1858169 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][CH2:15][O:16][C:17]1[C:26]2[C:21](=[CH:22][C:23]([Cl:37])=[C:24]([NH:27][C:28]([NH:30][C:31]3[CH:36]=[CH:35][N:34]=[CH:33][CH:32]=3)=[O:29])[CH:25]=2)[NH:20][C:19](=[O:38])[C:18]=1[C:39]1[S:40][CH:41]=[CH:42][CH:43]=1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:37][C:23]1[CH:22]=[C:21]2[C:26]([C:17]([O:16][CH2:15][CH2:14][CH:9]3[CH2:10][CH2:11][CH2:12][CH2:13][NH:8]3)=[C:18]([C:39]3[S:40][CH:41]=[CH:42][CH:43]=3)[C:19](=[O:38])[NH:20]2)=[CH:25][C:24]=1[NH:27][C:28]([NH:30][C:31]1[CH:32]=[CH:33][N:34]=[CH:35][CH:36]=1)=[O:29]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 539673912-{2-[7-Chloro-2-oxo-6-(3-pyridin-4-yl-ureido)-3-thiophen-2-yl-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 98496751-[7-Chloro-2-oxo-4-(2-piperidin-2-yl-ethoxy)-3-thiophen-2-yl-1,2-dihydroquinolin-6-yl]-3-pyridin-4-yl-urea

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-{2-[7-chloro-2-oxo-6-(3-pyridin-4-yl-ureido)-3-thiophen-2-yl-1,2-dihydroquinolin-4-yloxy]-ethyl }-piperidine-1-carboxylic acid tert-butyl ester in methylene chloride is added trifluoroacetic acid and the mixture stirred at room temperature. After 30 minutes, the mixture is concentrated in vacuo, resolvated in 10% ammonium hydroxide in methanol and concentrated once again. Purification by flash chromatography on silica gel gives the title compound.

後処理

  1. concentrationthe mixture is concentrated in vacuo
  2. concentrationconcentrated once again
  3. customPurification by flash chromatography on silica gel

出典と根拠

ORDレコード
ord-496efc17784e42e4a1bcfdcaae4297e6
出典データセット
uspto-grants-2000_11
特許番号
US06150522

反応ノート

読み込み中…