Hydrochloric Acid → HCID 178525233、化合物

HRID 1858502ノート

反応式

HRID 1858502 の反応式
[SH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10]CC)=[O:9])[N:6]=1.[OH-].[Na+].C(OCC)(=O)C.Cl>O1CCOCC1.O>[SH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[N:6]=1

参加物

7

反応物 4

HCID 313Hydrochloric Acid2 回HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 178470768HCID 178470768、化合物

生成物 1

HCID 178525233HCID 178525233、化合物収率 68.6%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of ethyl 2-mercapto-4-thiazole acetate (203 mg) in 1,4-dioxane (1.0 ml) was added 1N-sodium hydroxide solution (2.0 ml) at room temperature. After stirring at the same temperature for 2 hours, the solution was poured into a mixture of ethyl acetate and water, and adjusted to pH 8.0 with 1N-hydrochloric acid. The separated aqueous solution was adjusted to pH 3.0 with 1N-hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried over magnesium sulfate and evaporated under reduced pressure to give 2-mercapto-4-thiazole acetic acid (120 mg).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with saturated sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-bd34305476394c9da5f951aefd5e961e
出典データセット
uspto-grants-2000_11
特許番号
US06150351

反応ノート

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