5-Methylbenzofuran → 5-(Bromomethyl)benzofuran

HRID 1858579ノート

反応式

HRID 1858579 の反応式
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]2[O:6][CH:7]=[CH:8][C:4]=2[CH:3]=1.[Br:11]N1C(=O)CCC1=O.BrCC1C=CC2SC=CC=2C=1.CC1C=CC2SC=CC=2C=1>C(Cl)(Cl)(Cl)Cl>[Br:11][CH2:1][C:2]1[CH:10]=[CH:9][C:5]2[O:6][CH:7]=[CH:8][C:4]=2[CH:3]=1

参加物

6

反応物 4

HCID 331035-MethylbenzofuranHCID 67184N-bromobutanimideHCID 843465-Methylbenzo(b)thiopheneHCID 111604985-(Bromomethyl)benzo[b]thiophene

生成物 1

HCID 221285225-(Bromomethyl)benzofuran

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

By brominating 5-methyl-benzo[b]furan[Synth. Commun. 19, 257(1989)] with N-bromosuccinimide in carbon tetrachloride in an analogous manner to the procedure for the preparation of 5-bromomethyl-benzo[b]thiophene [J. Med. Chem. 34(1), 65(1991)] from 5-methyl-benzo[b]thiophene there was obtained 5-bromomethyl-benzo[b]furan as a light yellow solid; MS: 210, 212 (M)+.

出典と根拠

ORDレコード
ord-886f4a0fcbaf4e399e127918be063c3f
出典データセット
uspto-grants-2000_11
特許番号
US06150526

反応ノート

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