Hydrogen Peroxide → 3'-Phenylspiro[indene-2,2'-oxirane]-1,3-dione

HRID 1859078

反応式

HRID 1859078 の反応式
[CH:1](=[C:8]1[C:16](=[O:17])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]1=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:19]O.[OH-].[Na+].O>CO>[C:2]1([CH:1]2[C:8]3([C:9](=[O:18])[C:10]4[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=4)[C:16]3=[O:17])[O:19]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14798Sodium HydroxideHCID 2378222-Benzylidene-1,3-indandione

生成物 1

HCID 31422143'-Phenylspiro[indene-2,2'-oxirane]-1,3-dione

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
5 °C

実験手順

To a suspension of 2-benzylidene-1,3-indandione (20 g) in methanol (200 ml) was added 30% hydrogen peroxide (19 ml). The suspension was cooled to 5° C. and 1 N sodium hydroxide (2.1 ml) was added dropwise at such a rate as to keep the temperature below 15 ° C. After completed addition, stirring was continued at room temperature for 30 minutes. The mixture was then poured into water (1.2 L). The resulting crystalline precipitate was collected by filtration, washed on the filter with water (3×100 ml) and dried under high vacuum at room temperature for 24 hours, affording 3-phenylspiro[oxirane-2,2'-indan]-1',3'-dione as a yellow solid (17 g).

後処理

  1. customthe temperature below 15 ° C
  2. additionaddition
  3. filtrationThe resulting crystalline precipitate was collected by filtration
  4. washwashed on the
  5. filtrationfilter with water (3×100 ml)
  6. customdried under high vacuum at room temperature for 24 hours

出典と根拠

ORDレコード
ord-f5e821a3172d4116a7e7d12c233b35ab
出典データセット
uspto-grants-2000_11
特許番号
US06153645

関連ノート

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