Methyl iodide → Docosahexaenoyl choline iodide

HRID 1859091ノート

反応式

HRID 1859091 の反応式
[C:1]([O:24][CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])(=[O:23])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=[CH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].[I:30][CH3:31]>C(Cl)Cl>[I-:30].[C:1]([O:24][CH2:25][CH2:26][N+:27]([CH3:31])([CH3:29])[CH3:28])(=[O:23])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=[CH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 543902942-Dimethylaminoethyl docosahexaenoate

生成物 1

HCID 86754749Docosahexaenoyl choline iodide収率 96.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-dimethylaminoethyl docosahexaenoate (1.12 g, 2.80 mmol) in CH2Cl2 (10.0 mL) was added iodomethane (0.80 g, 5.60 mmol) dropwise at room temperature. The mixture was stirred at room temperature for 3 hr. The solvent and excess reagent was removed under reduced pressure and the residue was triturated with hexanes. The mixture was centrifuged and the supernatant was removed. The residue was dried under reduced pressure to provide the product, docosahexaenoyl choline iodide (1.46 g, 96%), as an off white solid.

後処理

  1. customThe solvent and excess reagent was removed under reduced pressure
  2. customthe residue was triturated with hexanes
  3. customthe supernatant was removed
  4. customThe residue was dried under reduced pressure

出典と根拠

ORDレコード
ord-a293ad9e71d64e2fa7d40639b215f019
出典データセット
uspto-grants-2000_11
特許番号
US06153653

反応ノート

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