Water → (S)-3-Hydroxy-4-methyl-3-(2-thiophen-3-yl-ethyl)-pentanoic Acid

HRID 1859525ノート

反応式

HRID 1859525 の反応式
C([O:5][C:6](=[O:20])[CH2:7][C@@:8]([OH:19])([CH2:12][CH2:13][C:14]1[CH:18]=[CH:17][S:16][CH:15]=1)[CH:9]([CH3:11])[CH3:10])(C)(C)C.[Li+].[OH-].O>CO>[OH:19][C@:8]([CH2:12][CH2:13][C:14]1[CH:18]=[CH:17][S:16][CH:15]=1)([CH:9]([CH3:10])[CH3:11])[CH2:7][C:6]([OH:20])=[O:5]

参加物

5

反応物 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 11141066(S)-3-hydroxy-4-methyl-3-(2-thiophen-3-yl-ethyl)-pentanoic acid tert-butyl ester

生成物 1

HCID 11831610(S)-3-Hydroxy-4-methyl-3-(2-thiophen-3-yl-ethyl)-pentanoic Acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The title compound was prepared as described in General Method 10 using (S)-3-hydroxy-4-methyl-3-(2-thiophen-3-yl-ethyl)-pentanoic acid tert-butyl ester (Example F-1 (S); 8 mmol), LiOH (16 mmol), H2O (5 mL), and MeOH (15 mL).

出典と根拠

ORDレコード
ord-1282734f967f4baa8cf55340ae302d64
出典データセット
uspto-grants-2003_03
特許番号
US06528510B1

反応ノート

読み込み中…