Pyridine → Toluene-4-thiosulfonic acid S-(2-amino-5-tert-butyl-benzothiazol-6-yl)ester

HRID 1859544ノート

反応式

HRID 1859544 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([SH:11])[C:8]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:7][C:5]=2[N:6]=1.N1C=CC=CC=1.[S:22](Br)([C:25]1[CH:31]=[CH:30][C:28]([CH3:29])=[CH:27][CH:26]=1)(=[O:24])=[O:23].C(Cl)(Cl)(Cl)Cl>CCOC(C)=O>[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([S:11][S:22]([C:25]3[CH:31]=[CH:30][C:28]([CH3:29])=[CH:27][CH:26]=3)(=[O:24])=[O:23])[C:8]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:7][C:5]=2[N:6]=1

参加物

6

反応物 4

HCID 1049PyridineHCID 5943Carbon TetrachlorideHCID 101308854-Methylbenzene-1-sulfonyl bromideHCID 225728932-Amino-5-tert-butyl-benzothiazole-6-thiol

生成物 1

HCID 54107741Toluene-4-thiosulfonic acid S-(2-amino-5-tert-butyl-benzothiazol-6-yl)ester

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

The title compound was prepared according to General Method 15 using 2-amino-5-tert-butyl-benzothiazole-6-thiol (7.0 g, 29 mmol), pyridine (2.3 g, 29 mmol), tosyl bromide (6.9 g, 29 mmol), carbon tetrachloride (100 mL), and EtOAc (100 mL). The crude reaction mixture was purified by flash chromatography (5% EtOAc in hexanes to 50% EtOAc in hexanes as eluents). MS(APCI): 393 (M+H).

後処理

  1. customThe crude reaction mixture
  2. customwas purified by flash chromatography (5% EtOAc in hexanes to 50% EtOAc in hexanes as eluents)

出典と根拠

ORDレコード
ord-17e00a8a4c6c4962966ccc24136b4e70
出典データセット
uspto-grants-2003_03
特許番号
US06528510B1

反応ノート

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