Methanol → 4-(6-tert-Butyl-5-mercapto-2,3-dihydro-indole-1-sulfonyl)-benzonitrile

HRID 1859554

反応式

HRID 1859554 の反応式
[C:1]([C:5]1[CH:13]=[C:12]2[C:8]([CH2:9][CH2:10][N:11]2[S:14]([C:17]2[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=2)(=[O:16])=[O:15])=[CH:7][C:6]=1[S:25]C#N)([CH3:4])([CH3:3])[CH3:2].S.[Na].[BH4-].[Na+].CO>CC(O)=O.O>[C:1]([C:5]1[CH:13]=[C:12]2[C:8]([CH2:9][CH2:10][N:11]2[S:14]([C:17]2[CH:18]=[CH:19][C:20]([C:21]#[N:22])=[CH:23][CH:24]=2)(=[O:15])=[O:16])=[CH:7][C:6]=1[SH:25])([CH3:4])([CH3:2])[CH3:3]

参加物

7

反応物 4

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 225730724-(6-tert-Butyl-5-thiocyanato-2,3-dihydro-indole-1-sulfonyl)-benzonitrileHCID 86586439Sodium hydrogen sulphide

生成物 1

HCID 225728314-(6-tert-Butyl-5-mercapto-2,3-dihydro-indole-1-sulfonyl)-benzonitrile

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

The title compound was prepared according to the General Method 14b using 4-(6-tert-butyl-5-thiocyanato-2,3-dihydro-indole-1-sulfonyl)-benzonitrile (prepared in Example MM; 6.0 g, 15 mmol), sodium hydrogen sulfide (2.53 g, 45.3 mmol), sodium borohydride (3.43 g, 90.7 mmol), MeOH (10 mL), water (5 mL), and AcOH (5 mL). The crude product was used further without any purification.

後処理

  1. customThe crude product was used further without any purification

出典と根拠

ORDレコード
ord-672e2232cea54aab88fb8df72f87cd75
出典データセット
uspto-grants-2003_03
特許番号
US06528510B1

関連ノート

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