Methanol → 6-tert-Butyl-7-mercapto-1,4-dihydro-quinoxaline-2,3-dione

HRID 1859573ノート

反応式

HRID 1859573 の反応式
[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[S:15]C#N)[NH:11][C:10](=[O:18])[C:9](=[O:19])[NH:8]2)([CH3:4])([CH3:3])[CH3:2].S.[Na].[BH4-].[Na+].CO>CC(O)=O>[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[SH:15])[NH:11][C:10](=[O:18])[C:9](=[O:19])[NH:8]2)([CH3:4])([CH3:2])[CH3:3]

参加物

6

反応物 4

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 225728766-Tert-butyl-7-thiocyanato-1,4-dihydro-quinoxaline-2,3-dioneHCID 86586439Sodium hydrogen sulphide

生成物 1

HCID 225727956-tert-Butyl-7-mercapto-1,4-dihydro-quinoxaline-2,3-dione

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

The title compound was prepared according to General Method 14b using 6-tert-butyl-7-thiocyanato-1,4-dihydro-quinoxaline-2,3-dione (prepared in Example CCC; 1.5 g, 9.1 mmol), sodium hydrogen sulfide (0.51 g, 27 mmol), sodium borohydride (2.1 g, 55 mmol), MeOH (30 mL), H20 (3 mL), and glacial AcOH (5 mL). The crude product was used without purification. MS(APCI): 251 (M+H).

後処理

  1. customThe crude product was used without purification

出典と根拠

ORDレコード
ord-8b65c9344574478c9886aa6dd1eaf533
出典データセット
uspto-grants-2003_03
特許番号
US06528510B1

反応ノート

読み込み中…