Methyl 2,2,2-trichloroacetimidate → 4-(2-Methoxy-ethoxy)-2-trichloromethyl-1H-benzoimidazole

HRID 18598

反応式

HRID 18598 の反応式
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH2:12])[C:7]=1[NH2:13].CO[C:16](=N)[C:17]([Cl:20])([Cl:19])[Cl:18]>C(O)(=O)C>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[C:7]2[N:13]=[C:16]([C:17]([Cl:20])([Cl:19])[Cl:18])[NH:12][C:8]=2[CH:9]=[CH:10][CH:11]=1

参加物

4

反応物 2

HCID 100479Methyl 2,2,2-trichloroacetimidateHCID 684142223-(2-Methoxyethoxy)benzene-1,2-diamine

生成物 1

HCID 686165704-(2-Methoxy-ethoxy)-2-trichloromethyl-1H-benzoimidazole

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

1.33 g (7.30 mmol) 3-(2-Methoxy-ethoxy)-benzene-1,2-diamine were dissolved in 35 mL acetic acid. 1.25 mL (10.22 mmol) 2,2,2-trichloro-acetimidic acid methyl ester were added and the resulting mixture was stirred for 2 h at room temperature. The mixture was concentrated under reduced pressure and the residue was co-distilled twice with 20 mL toluene to give crude 4-(2-Methoxy-ethoxy)-2-trichloromethyl-1H-benzoimidazole as a brown solid.

後処理

  1. concentrationThe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-84cd4e803db64d9184d9061c9ae843d5
出典データセット
uspto-grants-2010_06
特許番号
US07741341B2

関連ノート

読み込み中…