Sodium Hydroxide → 2-Butyl-3-[4-[2-(4'-carboxybiphenyl-4-carbonylamino)ethoxy]phenyl]propionic acid
反応式
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][C:33]([C:36]([O:38]C)=[O:37])=[CH:32][CH:31]=3)=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH:31]=[CH:32][C:33]([C:36]([OH:38])=[O:37])=[CH:34][CH:35]=3)=[CH:28][CH:29]=2)=[O:23])=[CH:16][CH:17]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]参加物
3
実験手順
In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(4′-methoxycarbonylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (243 mg), which is the product of Reference example 12, was reacted with aqueous sodium hydroxide solution (1N, 1.83 ml) and the reaction mixture was treated to give the title compound (163 mg) as a white powder.
後処理
- additionthe reaction mixture was treated