Sodium Hydroxide → HCID 10412670、化合物

HRID 1859872ノート

反応式

HRID 1859872 の反応式
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[O:36][CH3:37])=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[O:36][CH3:37])=[CH:28][CH:29]=2)=[O:23])=[CH:16][CH:17]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 18625856Ethyl 2-butyl-3-[4-[2-(2'-methoxybiphenyl-4-carbonylamino)ethoxy]phenyl]propionate

生成物 1

HCID 10412670HCID 10412670、化合物収率 88.2%

実験手順

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(2′-methoxybiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (750 mg), which is the product of Example 42, was reacted with aqueous sodium hydroxide solution (1N, 5.00 ml) and the reaction mixture was treated to give the title compound (625 mg) as a pale orange powder.

後処理

  1. additionthe reaction mixture was treated

出典と根拠

ORDレコード
ord-97c3b30546c544389ac699f3cada0a0c
出典データセット
uspto-grants-2003_03
特許番号
US06528525B1

反応ノート

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