Sodium Hydroxide → 2-(4-Pyridine-2-ylphenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionic acid

反応式

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:44]=[CH:43][C:10]([O:11][CH:12]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][NH:28][C:29](=[O:42])[C:30]3[CH:35]=[CH:34][C:33]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=4)=[CH:32][CH:31]=3)=[CH:21][CH:20]=2)[C:13]([O:15]CC)=[O:14])=[CH:9][CH:8]=1.[OH-].[Na+]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10]([O:11][CH:12]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][NH:28][C:29](=[O:42])[C:30]3[CH:35]=[CH:34][C:33]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=4)=[CH:32][CH:31]=3)=[CH:21][CH:20]=2)[C:13]([OH:15])=[O:14])=[CH:43][CH:44]=1

参加物

反応物 2

HCID 14798Sodium Hydroxide

HCID 18625869HCID 18625869、化合物

生成物 1

HCID 177956632-(4-Pyridine-2-ylphenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionic acid収率 81.9%

実験手順

In a similar manner to that described in Example 2, ethyl 2-(4-pyridine-2-ylphenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (500 mg), which is the product of Example 134, was reacted with aqueous sodium hydroxide solution (1N, 2.00 ml) and the reaction mixture was treated to give the title compound (390 mg) as a white powder.

後処理

additionthe reaction mixture was treated

出典と根拠

ORDレコード: ord-a5ed063452a64d8283ca7417074e45ab
出典データセット: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06528525B1

反応ノート

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