Ethyl 3-[4-(2-azidoethoxy)phenyl]-2-butyl-2-methylpropionate → Ethyl 3-[4-(2-aminoethoxy)phenyl]-2-butyl-2-methylpropionate

HRID 1860006ノート

反応式

HRID 1860006 の反応式
[N:1]([CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([CH2:21][CH2:22][CH2:23][CH3:24])([CH3:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:9][CH:8]=1)=[N+]=[N-]>[Pd]>[NH2:1][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([CH2:21][CH2:22][CH2:23][CH3:24])([CH3:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:9][CH:8]=1

参加物

3

反応物 1

HCID 18625962Ethyl 3-[4-(2-azidoethoxy)phenyl]-2-butyl-2-methylpropionate

生成物 1

HCID 18625809Ethyl 3-[4-(2-aminoethoxy)phenyl]-2-butyl-2-methylpropionate収率 96.1%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

In a similar manner to that described in Reference example 1(d), a reaction was carried out using ethyl 3-[4-(2-azidoethoxy)phenyl]-2-butyl-2-methylpropionate (2.73 g), which is the product of Reference example 10(f), and palladium on carbon (5%, 270 mg) and the reaction mixture was treated to afford the title compound (2.42 g) as a syrup.

後処理

  1. additionthe reaction mixture was treated

出典と根拠

ORDレコード
ord-e9a9009166a24c7fbf2181f16b036ea2
出典データセット
uspto-grants-2003_03
特許番号
US06528525B1

反応ノート

読み込み中…