1,1'-Carbonyldiimidazole → Ethyl 2-butyl-3-[4-[2-(4'-methoxymethoxy-3',5'-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate

反応式

[NH2:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([CH2:18][CH2:19][CH2:20][CH3:21])[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:7][CH:6]=1.[CH3:22][O:23][CH2:24][O:25][C:26]1[C:31]([CH3:32])=[CH:30][C:29]([C:33]2[CH:38]=[CH:37][C:36]([C:39](O)=[O:40])=[CH:35][CH:34]=2)=[CH:28][C:27]=1[CH3:42].C(N1C=CN=C1)(N1C=CN=C1)=O>>[CH2:18]([CH:12]([CH2:11][C:8]1[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH2:2][NH:1][C:39]([C:36]2[CH:37]=[CH:38][C:33]([C:29]3[CH:30]=[C:31]([CH3:32])[C:26]([O:25][CH2:24][O:23][CH3:22])=[C:27]([CH3:42])[CH:28]=3)=[CH:34][CH:35]=2)=[O:40])=[CH:6][CH:7]=1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:19][CH2:20][CH3:21]

参加物

反応物 3

HCID 682631,1'-Carbonyldiimidazole

HCID 186257084'-Methoxymethoxy-3',5'-dimethylbiphenyl-4-carboxylic acid

HCID 18625891Ethyl 3-[4-(2-aminoethoxy)phenyl]-2-butylpropionate

生成物 1

HCID 18625993Ethyl 2-butyl-3-[4-[2-(4'-methoxymethoxy-3',5'-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate収率 1,068.4%

実験手順

In a similar manner to that described in Example 5, a reaction was carried out using ethyl 3-[4-(2-aminoethoxy)phenyl]-2-butylpropionate (880 mg), which is the product of Reference example 6, 4′-methoxymethoxy-3′,5′-dimethylbiphenyl-4-carboxylic acid (859 mg), which is the product of reference example 17(b), and carbonyldiimidazole (577 mg) and the reaction mixture was treated to afford the desired compound (1 18 g) as colorless crystals.