Sodium Hydroxide → 3-[4-[2-(4'-Methoxymethoxy-3',5'-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionic acid
反応式
[CH3:1][O:2][CH2:3][O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([NH:20][CH2:21][CH2:22][O:23][C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH:31]([O:37][C:38]4[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=4)[C:32]([O:34]CC)=[O:33])=[CH:26][CH:25]=3)=[O:19])=[CH:14][CH:13]=2)=[CH:7][C:6]=1[CH3:44].[OH-].[Na+]>>[CH3:1][O:2][CH2:3][O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[CH:13]=[CH:14][C:15]([C:18]([NH:20][CH2:21][CH2:22][O:23][C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH:31]([O:37][C:38]4[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=4)[C:32]([OH:34])=[O:33])=[CH:26][CH:25]=3)=[O:19])=[CH:16][CH:17]=2)=[CH:7][C:6]=1[CH3:44]参加物
3
実験手順
In a similar manner to that described in Example 2, a reaction was carried out using ethyl 3-[4-[2-(4′-methoxymethoxy-3′,5′-dimethylbiphenyl-4-carbonylamino)ethoxy]phenyl]-2-phenoxypropionate (720 mg), which is the product of Reference example 24(a) and aqueous sodium hydroxide (1N, 2.40 ml) and the reaction mixture was treated to afford the title compound (520 mg) as a white powder.