Sodium Hydroxide → 6-(4-Methoxyphenyl)nicotinic acid

反応式

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][N:10]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[CH:11][N:10]=2)=[CH:7][CH:8]=1

参加物

反応物 2

HCID 14798Sodium Hydroxide

HCID 18625729HCID 18625729、化合物

生成物 1

HCID 186259336-(4-Methoxyphenyl)nicotinic acid収率 70.7%

実験手順

In a similar manner to that described in Example 2, a reaction was carried out using methyl 6-(4-methoxyphenyl)nicotinate (3.95 g) and aqueous sodium hydroxide solution (1N, 32.5 ml) and the reaction mixture was treated to afford the title compound (2.63 g) as colorless crystals.

後処理

additionthe reaction mixture was treated

出典と根拠

ORDレコード: ord-e70ca072ff05452e8dda5e203b16360c
出典データセット: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06528525B1

反応ノート

読み込み中…

参加物