Sodium Hydroxide → 6-(4-Fluorophenyl)nicotinic acid

HRID 1860037ノート

反応式

HRID 1860037 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][N:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([OH:14])=[O:13])=[CH:10][N:9]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 110317126-(4-Fluorophenyl)pyridine-3-carboxylic acid methyl ester

生成物 1

HCID 227301866-(4-Fluorophenyl)nicotinic acid収率 94.2%

実験手順

In a similar manner to that described in Example 2, a reaction was carried out using methyl 6-(4-fluorophenyl)nicotinate (390 mg) and aqueous sodium hydroxide solution (1N, 5.00 ml) and the reaction mixture was treated to afford the title compound (345 mg) as a pale yellow solid.

後処理

  1. additionthe reaction mixture was treated

出典と根拠

ORDレコード
ord-e68c8e300c7a42e58d9cf95081c2c404
出典データセット
uspto-grants-2003_03
特許番号
US06528525B1

反応ノート

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