Ethyl 3-(4-benzyloxyphenyl)-2-(4-methylphenoxy)propionate → Ethyl 3-(4-hydroxyphenyl)-2-(4-methylphenoxy)propionate

HRID 1860060ノート

反応式

HRID 1860060 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:22][C:23]2[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:22][C:23]2[CH:24]=[CH:25][C:26]([CH3:29])=[CH:27][CH:28]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1

参加物

3

反応物 1

HCID 18625971Ethyl 3-(4-benzyloxyphenyl)-2-(4-methylphenoxy)propionate

生成物 1

HCID 18626029Ethyl 3-(4-hydroxyphenyl)-2-(4-methylphenoxy)propionate収率 103.9%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

In a similar manner to that described in Reference example 1(d), a reaction was carried out using ethyl 3-(4-benzyloxyphenyl)-2-(4-methylphenoxy)propionate (2.84 g), which is the product of Reference example 35(b), and palladium on carbon (284 mg) and the reaction mixture was treated to afford the desired compound (2.27 g) as a syrup.

後処理

  1. additionthe reaction mixture was treated

出典と根拠

ORDレコード
ord-4a4b0b236bc4468495f668469663b16c
出典データセット
uspto-grants-2003_03
特許番号
US06528525B1

反応ノート

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