HCID 18622134、化合物 → 2-(4-Amino-2-fluorophenyl)acetonitrile
反応式
[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2C(=O)C3=CC=CC=C3C2=O)=[CH:6][C:5]=1[F:21])#[N:2]>CO.O.NN>[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[CH:6][C:5]=1[F:21])#[N:2]参加物
4
実験手順
To a solution of the compound (164 mg) obtained in Example 250 in methanol (5 ml), hydrazine monohydrate (0.057 ml) was added and heated under reflux for 3 h. The reaction mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent, n-hexane:ethyl acetate=6:4) to give 67 mg of the titled compound (yield, 76%).
後処理
- temperatureheated
- temperatureunder reflux for 3 h
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe resulting residue was purified by silica gel column chromatography (eluent, n-hexane:ethyl acetate=6:4)
出典と根拠
- ORDレコード
- ord-313be450829242208c16baadb16639fc
- 出典データセット
- uspto-grants-2003_03
- 特許番号
- US06534546B1
反応ノート
読み込み中…