Ethanolamine → Methanesulfonic acid 8-(2-hydroxyacetylamino)naphthalen-2-yl ester
反応式
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[CH:14]=[C:13]([O:16][S:17]([CH3:20])(=[O:19])=[O:18])[CH:12]=[CH:11]2)=[O:4].C(CN)[OH:22]>C(OC(C)=O)(C)C>[OH:22][CH2:2][C:3]([NH:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[CH:14]=[C:13]([O:16][S:17]([CH3:20])(=[O:19])=[O:18])[CH:12]=[CH:11]2)=[O:4]参加物
4
実験手順
To a solution of ester from Step B (11.0 g, 39.5 mmol) in 150 mL of i-PrOAc at room temperature was added ethanolamine (12.0 mL, 199 mmol). After 18 hours, the reaction was partitioned between EtOAc and water, and the organic layer was extracted with saturated brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide a dark oil.
後処理
- customthe reaction was partitioned between EtOAc and water
- extractionthe organic layer was extracted with saturated brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
- customto provide a dark oil
出典と根拠
- ORDレコード
- ord-fb6d84caeb864c26a6a86166673ff955
- 出典データセット
- uspto-grants-2003_03
- 特許番号
- US06534506B2
反応ノート
読み込み中…