Potassium tert-butoxide → 2-methyl-2H-pyran-3,5(4H,6H)-dione

HRID 1862447ノート

反応式

HRID 1862447 の反応式
CC(C)([O-])C.[K+].[CH3:7][CH:8]([O:12][CH2:13][C:14]([O:16]C)=O)[C:9](=[O:11])[CH3:10]>C(O)(C)(C)C.CCOCC>[CH3:7][CH:8]1[C:9](=[O:11])[CH2:10][C:14](=[O:16])[CH2:13][O:12]1

参加物

5

反応物 2

HCID 23665647Potassium tert-butoxideHCID 71360827Methyl (1-methyl-2-oxopropoxy)acetate

生成物 1

HCID 234974742-methyl-2H-pyran-3,5(4H,6H)-dione

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6386tert-Butanol溶媒

実験手順

Potassium tert-butoxide in tert-butanol (1 M, 203 mL) and the product from Example 44B (15.5 g, 97 mmol) in ether (55 mL) were processed as described in Example 43C. The residue was purified on silica gel eluting with ethyl acetate:formic acid:water:hexane (200:1:1:200) provided the title compound. 1H NMR (CDCl3) δ 1.48 (d, 3H), 3.43 (d, 1H), 3.92 (d, 1H), 3.97 (q, 1H), 4.04 (d, 1H), 4.44 (d, 1H).

後処理

  1. customThe residue was purified on silica gel eluting with ethyl acetate:formic acid:water:hexane (200:1:1:200)

出典と根拠

ORDレコード
ord-cc7df6c706fb4b2ba3e108b6efc09c26
出典データセット
uspto-grants-2003_03
特許番号
US06538004B2

反応ノート

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