Water → Ergosterol, acetate

HRID 1862550ノート

反応式

HRID 1862550 の反応式
[CH3:1][C@@H:2]([C@@H:10]1[C@@:14]2([CH3:29])[CH2:15][CH2:16][C@@H:17]3[C@@:22]4([CH3:28])[CH2:23][CH2:24][C@H:25]([OH:27])[CH2:26][C:21]4=[CH:20][CH:19]=[C:18]3[C@@H:13]2[CH2:12][CH2:11]1)/[CH:3]=[CH:4]/[C@@H:5]([CH:7]([CH3:9])[CH3:8])[CH3:6].[C:30](OC(=O)C)(=[O:32])[CH3:31].O>N1C=CC=CC=1>[C:30]([O:27][C@H:25]1[CH2:24][CH2:23][C@@:22]2([CH3:28])[C:21](=[CH:20][CH:19]=[C:18]3[C@@H:17]2[CH2:16][CH2:15][C@@:14]2([CH3:29])[C@H:13]3[CH2:12][CH2:11][C@@H:10]2[C@H:2]([CH3:1])/[CH:3]=[CH:4]/[C@H:5]([CH3:6])[CH:7]([CH3:8])[CH3:9])[CH2:26]1)(=[O:32])[CH3:31]

参加物

5

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 444679Ergosterol

生成物 1

HCID 6436903Ergosterol, acetate収率 74%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 50 gm (0.13 mol) of ergosterol (1) in 300 mL of anhydrous pyridine was added 33.3 mL (0.35 mol) of acetic anhydride. The mixture was stirred at room temperature overnight and then 600 mL of water was added. The precipitate was filtered and washed three times with 200 mL portions of acetonitrile and then air dried to yield 42.0 g (74%) of (2).

後処理

  1. filtrationThe precipitate was filtered
  2. washwashed three times with 200 mL portions of acetonitrile
  3. customair dried

出典と根拠

ORDレコード
ord-087be7b33c154d15bef47192ea7389b1
出典データセット
uspto-grants-2003_03
特許番号
US06538037B2

反応ノート

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