Ethyl bromoacetate → Ethyl 2-(5-chloro-2-methoxyphenoxy)acetate

HRID 1862610ノート

反応式

HRID 1862610 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([OH:8])[CH:7]=1.C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([CH:7]=1)[O:8][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]

参加物

5

反応物 3

HCID 7748Ethyl bromoacetateHCID 10796Cesium carbonateHCID 588774Phenol, 5-chloro-2-methoxy-

生成物 1

HCID 18620157Ethyl 2-(5-chloro-2-methoxyphenoxy)acetate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 5-chloro-2-methoxyphenol (488 mg) in acetone (15 ml) were added cesium carbonate (1.20 g) and ethyl bromoacetate (375 μl), and the mixture was stirred for 1 hour at room temperature. The insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. Purification of the residue by flash column chromatography on silica gel (eluent: hexane/ethyl acetate=6/1) gave ethyl 2-(5-chloro-2-methoxyphenoxy)acetate (572 mg).

後処理

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customPurification of the residue by flash column chromatography on silica gel (eluent: hexane/ethyl acetate=6/1)

出典と根拠

ORDレコード
ord-6bb59a5168c14f8da619c4cdbac83b5c
出典データセット
uspto-grants-2003_03
特許番号
US06538152B1

反応ノート

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