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Hydrochloric Acid → 2-[2-bromo-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetic acid

HRID 1862630
ノート
印刷プレビュー

反応式

HRID 1862630 の反応式
[Br:1][C:2]1[CH:14]=[C:13]([CH2:15][CH2:16][NH:17][C@@H:18]([CH3:28])[C@H:19]([OH:27])[C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=2)[CH:12]=[CH:11][C:3]=1[O:4][CH2:5][C:6]([O:8]CC)=[O:7].[OH-].[Na+].Cl>C(O)C>[Br:1][C:2]1[CH:14]=[C:13]([CH2:15][CH2:16][NH:17][C@@H:18]([CH3:28])[C@H:19]([OH:27])[C:20]2[CH:21]=[CH:22][C:23]([OH:26])=[CH:24][CH:25]=2)[CH:12]=[CH:11][C:3]=1[O:4][CH2:5][C:6]([OH:8])=[O:7]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15895329ethyl 2-[2-bromo-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetate

生成物 1

HCID 115536082-[2-bromo-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetic acid収率 28.7%

試薬・触媒・溶媒 1

HCID 702
Ethanol
溶媒

実験手順

To a solution of ethyl 2-[2-bromo-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetate (327 mg) in ethanol (3.3 ml) was added 1N aqueous sodium hydroxide solution (1.45 ml), and the mixture was stirred for 15 hours at room temperature. 1N Hydrochloric acid (1.45 ml) was added to the stirred reaction mixture under ice-cooling, and the solvent was removed under reduced pressure. To the residue was added water, and the resulting insoluble material was collected by filtration to give 2-[2-bromo-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetic acid (88 mg).

後処理

  1. temperaturecooling
  2. customthe solvent was removed under reduced pressure
  3. additionTo the residue was added water
  4. filtrationthe resulting insoluble material was collected by filtration

出典と根拠

ORDレコード
ord-ee435a088b224a548aa7b4aac5a0e8cb
出典データセット
uspto-grants-2003_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06538152B1

反応ノート

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