Butylamine → N-Butyl-3-methyl-1,2,4-oxadiazol-5-amine

反応式

[CH3:1][C:2]1[N:6]=[C:5](C(Cl)(Cl)Cl)[O:4][N:3]=1.[CH2:11]([NH2:15])[CH2:12][CH2:13][CH3:14]>>[CH2:11]([NH:15][C:5]1[O:4][N:3]=[C:2]([CH3:1])[N:6]=1)[CH2:12][CH2:13][CH3:14]

参加物

反応物 2

HCID 8007Butylamine

HCID 709533-Methyl-5-(trichloromethyl)-1,2,4-oxadiazole

生成物 1

HCID 20393636N-Butyl-3-methyl-1,2,4-oxadiazol-5-amine

実験手順

3-Methyl-5-trichloromethyl-1,2,4oxadiazole (43 g, 0.21 mole) was added to n-butylamine (46.75 g, 0.63 mole) and stirred at room temperature overnight. Excess amine was removed under vacuum and the residue distilled (oil bath 110° C./0.5 mmHg). Recrystallisation from petroleum ether 60°-80° C. gave the title compound as white plates 26 g, m.p. 62°-65° C.

後処理

customExcess amine was removed under vacuum
distillationthe residue distilled (oil bath 110° C./0.5 mmHg)
customRecrystallisation from petroleum ether 60°-80° C.

出典と根拠

ORDレコード: ord-77690477e8324b2fa81e0102d13eff02
出典データセット: uspto-grants-1979_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04166818

反応ノート

読み込み中…

参加物