4-Benzyloxybenzotrifluoride → 4-(Trifluoromethyl)phenol

HRID 1863263ノート

反応式

HRID 1863263 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[F:16][C:15]([F:17])([F:18])[C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=1

参加物

5

反応物 2

HCID 27981684-BenzyloxybenzotrifluorideHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 678744-(Trifluoromethyl)phenol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 390 g. of 4-trifluoromethylphenyl benzyl ether in 3580 ml. of ethanol was placed in a low pressure hydrogenation vessel along with 30 g. of 5 percent palladium-on-carbon. An initial hydrogen pressure of 60 psi was used and the solution was hydrogenated at room temperature until the theoretical uptake of hydrogen had been achieved--about 2 hours. The catalyst was removed by filtration. Concentration of the filtrate yielded 4-trifluoromethylphenol, distilling in the range 51°-54° C. at 6 torr. Yield=212 gms. (84.5 percent).

後処理

  1. customabout 2 hours
  2. customThe catalyst was removed by filtration

出典と根拠

ORDレコード
ord-328161224b5440f0b9296079639b3a53
出典データセット
uspto-grants-1979_09
特許番号
US04168388

反応ノート

読み込み中…