Thionyl Chloride → 6,7-Dimethoxy-2-naphthoyl chloride

HRID 1863475ノート

反応式

HRID 1863475 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]=[C:8]([C:15]([OH:17])=O)[CH:7]=[CH:6]2.S(Cl)([Cl:20])=O>CN(C)C=O.C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]=[C:8]([C:15]([Cl:20])=[O:17])[CH:7]=[CH:6]2

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 2830286,7-Dimethoxy-2-naphthoic acid

生成物 1

HCID 218249396,7-Dimethoxy-2-naphthoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 241Benzene溶媒

実験手順

To a solution containing 15.0 g. of 6,7-dimethoxy-2-naphthoic acid and one drop of dimethylformamide in 200 ml. of benzene was added 25 ml. of thionyl chloride. After heating one hour under reflux the mixture was evaporated to dryness in vacuo. Additional benzene was added and evaporation repeated to give 6,7-dimethoxy-2-naphthoyl chloride which was used directly in the preparation of 6,7-dimethoxy-2-naphthamide as described hereinabove in Example 113.

後処理

  1. additionTo a solution containing 15.0 g
  2. temperatureAfter heating one hour
  3. temperatureunder reflux the mixture
  4. customwas evaporated to dryness in vacuo
  5. additionAdditional benzene was added
  6. customevaporation

出典と根拠

ORDレコード
ord-4501dfb1c86a418b9cade2b8f6690a3d
出典データセット
uspto-grants-1979_09
特許番号
US04169108

反応ノート

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