Dichloromethane → 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)pyrazine
反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[N:7]2[CH:8]=[CH:9][N:10]=[CH:11][C:6]2=[N:5][N:4]=1.ClCCl>[Pd].C(O)C>[F:12][C:2]([F:1])([F:13])[C:3]1[N:7]2[CH2:8][CH2:9][NH:10][CH2:11][C:6]2=[N:5][N:4]=1参加物
5
実験手順
3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine (540 mg, 2.87 mmol, from Step A) was hydrogenated under atmospheric hydrogen with 10% Pd/C (200 mg) as a catalyst in ethanol (10 mL) at ambient temperature for 18 h. Filtration through Celite followed by concentration gave a dark colored oil. Dichloromethane was added to the above oil and the insoluble black precipitate was filtered off. Concentration of the filtrate gave the title compound as an oil.
後処理
- filtrationFiltration through Celite
- concentrationfollowed by concentration
- customgave a dark colored oil
- filtrationthe insoluble black precipitate was filtered off
出典と根拠
- ORDレコード
- ord-15ae0166de7c4bc0941e3f23c4d661f1
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07625888B2
反応ノート
読み込み中…