Hydrochloric Acid → 2-Amino-N-(2-hydroxyethyl)benzamide

HRID 1864041ノート

反応式

HRID 1864041 の反応式
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[CH2:13]([CH2:15][NH2:16])[OH:14].Cl>O>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:16][CH2:15][CH2:13][OH:14])=[O:4]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 700EthanolamineHCID 8359Isatoic Anhydride

生成物 1

HCID 30164842-Amino-N-(2-hydroxyethyl)benzamide収率 71.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A round-bottomed flask was charged with isatoic anhydride (5.0 g, 0.030 mol) and 40 mL water. Ethanolamine (2.21 mL, 0.036 mol) was added slowly to the reaction mixture. The reaction mixture was acidified with 1N HCl and extracted with EtOAc. The aqueous layer was basified with 6N NaOH and extracted with EtOAc. The EtOac layer was dried over Na2SO4, filtered, and concentrated to dryness to afford 2-amino-N-(2-hydroxyethyl)benzamide (3.86 g, 70%).

後処理

  1. extractionextracted with EtOAc
  2. extractionextracted with EtOAc
  3. dry with materialThe EtOac layer was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-4173bff4a4954617b3adcf05079719aa
出典データセット
uspto-grants-2009_12
特許番号
US07625903B2

反応ノート

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