Piperazine → HCID 67141098、化合物
反応式
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.C(N(CC)CC)C>C(#N)C>[Br:1][C:2]1[C:3]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1参加物
5
実験手順
A solution of 3-bromo-2-chloro-6-picoline (0.2 g), piperazine (0.083 g) and triethylamine (0.096 g) in acetonitrile (5 ml) was heated in the microwave apparatus: 30 min at 120° C. followed by 60 min at 150° C. and 30 min at 170° C. The mixture was concentrated and the product was purified by chromatography (SiO2, CH2Cl2=>CH2Cl2/CH3OH 4:1) to give 1-(3-bromo-6-methyl-pyridin-2-yl)-piperazine (0.05 g) as a light yellow solid.
後処理
- concentrationThe mixture was concentrated
- customthe product was purified by chromatography (SiO2, CH2Cl2=>CH2Cl2/CH3OH 4:1)
出典と根拠
- ORDレコード
- ord-23966f69fd7f4fbd94dde6e0ed513270
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07625902B2
反応ノート
読み込み中…