Trifluoroacetic acid → HCID 68592998、化合物

HRID 1864490ノート

反応式

HRID 1864490 の反応式
[OH:1][C@H:2]1[CH2:6][N:5](C(OC(C)(C)C)=O)[C@@H:4]([CH2:14][OH:15])[CH2:3]1.[C:16]([OH:22])([C:18]([F:21])([F:20])[F:19])=[O:17]>C(Cl)Cl>[F:19][C:18]([F:21])([F:20])[C:16]([OH:22])=[O:17].[OH:15][CH2:14][C@@H:4]1[NH:5][CH2:6][C@H:2]([OH:1])[CH2:3]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 10680283tert-Butyl (2R,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

生成物 1

HCID 68592998HCID 68592998、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1,1-Dimethylethyl(2R,4R)-4-hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylate (0.185 g, 0.852 mmol) was stirred in a 1:1 solution of methylene chloride:TFA for 14 hours. The reaction was concentrated, and the crude material was used without further purification. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.5 (m, 1H), 2.2 (m, 4H), 3.0 (m, 1H), 3.1 (m, 1H), 3.6 (m, 3H), 4.3 (m, 1H), 5.3 (s, br, 2H), 8.6 (s, br, 1H), 9.2 (s, br, 1H).

後処理

  1. concentrationThe reaction was concentrated
  2. customthe crude material was used without further purification

出典と根拠

ORDレコード
ord-c024fe85139b458b96c0a4a5bd415756
出典データセット
uspto-grants-2009_12
特許番号
US07625909B2

反応ノート

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