HCID 22278860、化合物 → 4-Dimethylamino-3-ethyl-3-methylpiperidine

HRID 1865263ノート

反応式

HRID 1865263 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:16])[CH3:15])[C:10]([CH2:18][CH3:19])([CH3:17])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[OH-].[OH-].[Pd+2]>[CH3:15][N:14]([CH3:16])[CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][C:10]1([CH2:18][CH3:19])[CH3:17]

参加物

5

反応物 1

HCID 22278860HCID 22278860、化合物

生成物 1

HCID 222788404-Dimethylamino-3-ethyl-3-methylpiperidine

試薬・触媒・溶媒 3

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒HCID 178418361HCID 178418361、化合物溶媒

実験手順

A mixture of 20% Pd(OH)2 on carbon (0.7 g) and 1-benzyl-4-dimethylamino-3-ethyl-3-methyl piperidine (6 g, 23 mmol) in methanol (50 ml) was stirred in hydrogen atmosphere (1 atm.) for 48 hr at room temperature. The catalyst was filtered off, washed with methanol and filtrate was concentrated to afford 4-dimethylamino-3-ethyl-3-methylpiperidine. Yield 2.8 g (72%), C10H22N2, m/z 171 (M+1).

後処理

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol and filtrate
  3. concentrationwas concentrated

出典と根拠

ORDレコード
ord-4b84e645a5854a6282e9f8d096d870d0
出典データセット
uspto-grants-2009_12
特許番号
US07626032B2

反応ノート

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