Methylamine → Adamantan-1-yl-methylamino-acetic acid

HRID 1865714ノート

反応式

HRID 1865714 の反応式
[C:1]12([CH:11](I)[C:12]([OH:14])=[O:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[CH3:16][NH2:17]>O1CCCC1>[C:1]12([CH:11]([NH:17][CH3:16])[C:12]([OH:14])=[O:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

参加物

4

反応物 2

HCID 6329MethylamineHCID 13022564Adamantan-1-yl-iodo-acetic acid

生成物 1

HCID 11229817Adamantan-1-yl-methylamino-acetic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Adamantan-1-yl-iodo-acetic acid (7.86 g, 24.55 mmol, P. A. Krasutskii. et. Al. J. Org. Chem. USSR (Engl. Trans.); 1985; 1327-1332) is refluxed with 100 mL of 2M methylamine in tetrahydrofuran for 18 hours. The solvent is evaporated in vacuo, and the residue treated with water. The pH is adjusted to 6 and the resulting solid collected and dried to give 2.16 g of the title compound as a white solid. MS: m/z 224.2 (M+1).

後処理

  1. customThe solvent is evaporated in vacuo
  2. additionthe residue treated with water
  3. customthe resulting solid collected
  4. customdried

出典と根拠

ORDレコード
ord-cb7026072cad42dab14daa795ec7ff52
出典データセット
uspto-grants-2009_12
特許番号
US07626023B2

反応ノート

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