Sodium Hydroxide → Benzeneethanamine, 4-iodo-alpha-methyl-, (alphaR)-
反応式
FC(F)(F)C([NH:5][C@H:6]([CH3:15])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([I:14])=[CH:10][CH:9]=1)=O.[OH-].[Na+]>O1CCOCC1.C(OCC)(=O)C.O>[I:14][C:11]1[CH:10]=[CH:9][C:8]([CH2:7][C@H:6]([NH2:5])[CH3:15])=[CH:13][CH:12]=1参加物
6
実験手順
To a solution of 2,2,2-trifluoro-N-[(1R)-2-(4-iodophenyl)-1-methylethyl]acetamide in dioxane (10 ml) was added 1N sodium hydroxide (12 ml) and the mixture was stirred for 1 hour at room temperature. The mixture was diluted with ethyl acetate and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and evaporated to give [(1R)-2-(4-iodophenyl)-1-methylethyl]amine (2.34 g) as a yellow oil.
後処理
- customThe organic layer was separated
- washwashed with brine
- dry with materialdried over magnesium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-4e69aa0d8d4842d1b1c01834ad22c1e3
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07629366B2
反応ノート
読み込み中…