Ammonium formate → HCID 178448358、化合物

HRID 1866752

反応式

HRID 1866752 の反応式
[CH3:1][CH:2]([C@H:4]([NH2:23])[C:5]([O:7][CH2:8][CH2:9][O:10][CH2:11][N:12]1[C:16]2[NH:17][C:18]([NH2:22])=[N:19][C:20](=[O:21])[C:15]=2[N:14]=[CH:13]1)=[O:6])[CH3:3].[CH:24]([O-])=[O:25].[NH4+]>CN1CCCC1=O>[CH3:3][CH:2]([C@H:4]([NH:23][CH:24]=[O:25])[C:5]([O:7][CH2:8][CH2:9][O:10][CH2:11][N:12]1[C:16]2[NH:17][C:18]([NH2:22])=[N:19][C:20](=[O:21])[C:15]=2[N:14]=[CH:13]1)=[O:6])[CH3:1]

参加物

4

反応物 2

HCID 2723923Ammonium formateHCID 178448382HCID 178448382、化合物

生成物 1

HCID 178448358HCID 178448358、化合物

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
125 °C

実験手順

A 100 ml round bottom flask equipped with magnetic stir bar is charged with 7.25 gr Valacyclovir (20 mmol), 1.97 gr ammonium formate (31.2 mmol), NMP (N-Methyl-pyrrolidone) (15 ml) is added and stirring is started. The resulting mixture is placed in an oil bath that is heated to 125° C. for 2 hrs. The mixture is removed from the oil bath, allowed to cool to room temperature, and the solvent is removed under reduced pressure using high vac. pump. The residue is crystallized from 150 ml boiling water to give 6.0 gr at the purity of 80%.

後処理

  1. customA 100 ml round bottom flask equipped with magnetic stir bar
  2. additionis added
  3. customThe resulting mixture is placed in an oil bath
  4. customThe mixture is removed from the oil bath
  5. temperatureto cool to room temperature
  6. customthe solvent is removed under reduced pressure
  7. customThe residue is crystallized from 150 ml
  8. customto give 6.0 gr at the purity of 80%

出典と根拠

ORDレコード
ord-43fa7e8655014d38a105c0e79732f646
出典データセット
uspto-grants-2009_12
特許番号
US07629461B2

関連ノート

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