HCID 178465384、化合物 → HCID 178463402、化合物
反応式
C(OC(=O)[NH:10][CH:11]([C:13]1[NH:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:17]=1)[CH3:12])C1C=CC=CC=1>CO.[Pd]>[C:18]1([C:16]2[N:17]=[C:13]([CH:11]([NH2:10])[CH3:12])[NH:14][CH:15]=2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1参加物
4
実験手順
To a solution of [1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-carbamic acid benzyl ester (1.5 g, 4.67 mmol) in methanol (25 mL) was added 10% palladium on carbon (0.16 g). The mixture was shaken in a hydrogenation apparatus at rt under a hydrogen atmosphere (10 psi) for 8 h. Filtration followed by evaporation to dryness under reduced pressure yielded the crude product 1-(4-phenyl-1H-imidazol-2-yl)-ethylamine.
後処理
- filtrationFiltration
- customfollowed by evaporation to dryness under reduced pressure
出典と根拠
- ORDレコード
- ord-6aa684c62046453f8ade39a3e22573b3
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07629488B2
反応ノート
読み込み中…