2-Chloro-4-t-butylbenzyl alcohol → 4-tert-Butyl-2-chlorobenzaldehyde

HRID 1867245ノート

反応式

HRID 1867245 の反応式
[Cl:1][C:2]1[CH:9]=[C:8]([C:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:9]=[C:8]([C:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

参加物

4

反応物 1

HCID 688990782-Chloro-4-t-butylbenzyl alcohol

生成物 1

HCID 178596104-tert-Butyl-2-chlorobenzaldehyde収率 79%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

反応条件

温度
50 °C

実験手順

The alcohol compound (195 mg, 0.981 mmol) obtained in Step 1-3 was dissolved in chloroform (5 ml). Activated manganese dioxide (1.27 g) was added to the obtained solution, and they were violently stirred at 50° C. for 2 hours. After leaving to cool, manganese dioxide was filtered out, and the filtrate was concentrated under reduced pressure. After the purification by the silica gel column chromatography, 2-chloro-4-t-butylbenzaldehyde (yield: 152 mg, 79%) was obtained.

後処理

  1. customAfter leaving
  2. temperatureto cool
  3. filtrationmanganese dioxide was filtered out
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customAfter the purification by the silica gel column chromatography

出典と根拠

ORDレコード
ord-fef5663a8e664824a8669e85124167dc
出典データセット
uspto-grants-2009_12
特許番号
US07632830B2

反応ノート

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