1-Benzyl-3-methyl-1,4-diazepan-5-one → 3-Methyl-1,4-diazepan-5-one
反応式
C([N:8]1[CH2:14][CH2:13][C:12](=[O:15])[NH:11][CH:10]([CH3:16])[CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][CH:10]1[NH:11][C:12](=[O:15])[CH2:13][CH2:14][NH:8][CH2:9]1参加物
4
実験手順
A mixture of 1-benzyl-3-methyl-[1,4]diazepan-5-one (1.88 g, 8.62 mmol) and palladium (10% on activated charcoal, 188 mg) in ethanol (50 ml) was stirred at room temperature under a hydrogen atmosphere (3 bar). After 18 h, the catalyst was removed by filtration and the filtrate evaporated to afford the title compound (1.12 g, 99%). White solid, MS: m/e=128 (M+).
後処理
- customthe catalyst was removed by filtration
- customthe filtrate evaporated
出典と根拠
- ORDレコード
- ord-cbc7d36e98224cc0ba61da0a9a4e1cfb
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07632829B2
反応ノート
読み込み中…