Trimethyl((tributylstannyl)ethynyl)silane → 2-(4-Hydroxyphenyl)-4-[(trimethylsilyl)ethynyl]quinolin-6-ol

HRID 1867481

反応式

HRID 1867481 の反応式
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)[CH:3]=1.[CH3:20][Si:21]([C:24]#[C:25][Sn](CCCC)(CCCC)CCCC)([CH3:23])[CH3:22]>>[OH:19][C:16]1[CH:17]=[CH:18][C:13]([C:4]2[CH:3]=[C:2]([C:25]#[C:24][Si:21]([CH3:23])([CH3:22])[CH3:20])[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=3)[N:5]=2)=[CH:14][CH:15]=1

参加物

3

反応物 2

HCID 639663Trimethyl((tributylstannyl)ethynyl)silaneHCID 1354548024-Bromo-2-(4-hydroxyphenyl)quinolin-6-ol

生成物 1

HCID 1354097832-(4-Hydroxyphenyl)-4-[(trimethylsilyl)ethynyl]quinolin-6-ol収率 83%

実験手順

This compound was prepared from 6a and (trimethylsilylethynyl)tributyltin according to method J. Yellow powder; Yield: 83%; mp 210° C. (dec.); 1H-NMR (300 MHz, acetone-d6) δ 0.38 (s, 9H), 7.02 (d, J=8.7 Hz, 2H), 7.44 (dd, J=9.1, 2.7 Hz, 1H), 7.63 (d, J=2.7 Hz, 1H), 7.99 (d, J=9.1 Hz, 1H), 8.05 (s, 1H), 8.18 (d, J=8.7 Hz, 2H), 8.70 (s, 1H), 9.15 (s, 1H); MS (ESI) m/z 332 ([M−H]−), 334 ([M+H]+); Anal. Calcd for C20H19NO2Si: C, 72.04; H, 5.74; N, 4.20. Found: C, 71.67; H, 5.79; N, 4.07.

出典と根拠

ORDレコード
ord-d17134ef89b64d14b2e74af40e954c34
出典データセット
uspto-grants-2009_12
特許番号
US07632845B2

関連ノート

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