Hydrogen Bromide → HCID 136388604、化合物
反応式
[N:1]1[O:5][N:4]=[C:3]2[CH:6]=[C:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][CH2:17][CH2:18][F:19])=[CH:12][C:11]=3[O:20]C)[CH:8]=[CH:9][C:2]=12.Br>C(O)(=O)C>[N:1]1[O:5][N:4]=[C:3]2[CH:6]=[C:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][CH2:17][CH2:18][F:19])=[CH:12][C:11]=3[OH:20])[CH:8]=[CH:9][C:2]=12参加物
4
実験手順
10 mg (0.03 mmol) of (4-benzo[1,2,5]oxadiazol-5-yl-3-methoxy-phenyl)-(2-fluoro-ethyl)-amine are dissolved in 0.3 mL acetic acid and 0.3 mL hydrobromic acid (33% in acetic acid) and stirred at 80 QC for 72 h. Then the solvents are removed. The mixture of starting material and desired product can be separated by HPLC (20 to 100% CH3CN/H2O (6′), 100% CH3CN (1.5°), 100 to 20% CH3CN/H2O (0.5°): product elutes after 4.5°). MS(ES+): 274 (M+1).
後処理
- customThen the solvents are removed